Albumin-to-creatinine ratio in random urine samples might replace 24-h urine collections in screening for micro- and macroalbuminuria in pregnant woman with type 1 diabetes.

P re-eclampsia, a clinical syndrome of unknown etiology, is among the most common reasons for perinatal and maternal mortality (1). The incidence of pre-eclampsia in women with type 1 diabetes is considerably higher (10–20%) than in the background population (4– 5%) (2). Microalbuminuria, defined as a urinary albumin excretion from 30 to 300 mg/24 h before or in early pregnancy has proven to be a good risk marker for preeclampsia in women with type 1 diabetes (3). However, the urinary albumin status is often not known at booking for pregnancy. The traditional method for diagnosing microalbuminuria, collection of 24-h urine samples, is cumbersome and time consuming and may be associated with collection errors and poor compliance. The aim of this study was to determine whether measurement of the albumin-to-creatinine ratio in random urine samples can replace 24-h urine collection in screening for microand macroalbuminuria in pregnant women with type 1 diabetes.