No consistent evidence for association between mtDNA variants and Alzheimer disease.
نویسندگان
چکیده
OBJECTIVE Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain. METHODS We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis. RESULTS In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD. CONCLUSION The current evidence linking common mtDNA variations with AD is not compelling.
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ورودعنوان ژورنال:
- Neurology
دوره 78 14 شماره
صفحات -
تاریخ انتشار 2012