Molecular mimicry in Campylobacter jejuni lipopolysaccharides and the development of Guillain-Barré syndrome.
نویسندگان
چکیده
1. Preston D, Therasse D, Zeckel ML. Cefaclor and cefuroxime axetil in the treatment of otitis media—an alternative view [letter]. J Infect Dis 1998;178:1547–8 2. Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997;176:1253–9. 3. Dagan R, Leibovitz E, Greenberg D, Yagupsky P, Fliss DM, Leiberman A. Early eradication of pathogens from middle ear fluid during antibiotic treatment of acute otitis media is associated with improved clinical outcome. Pediatr Infect Dis J 1998;17:776–82. 4. Craig WA, Andes D. Pharmacokinetics and pharmacodynamics of antimicrobials in otitis media. Pediatr Infect Dis J 1996;15:255–9. Reprints or correspondence: Dr. Ron Dagan, Pediatric Infectious Disease Unit, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel ([email protected]).
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OBJECTIVE Molecular mimicry between Campylobacter jejuni lipo-oligosaccharides (LOSs) and human gangliosides GM1 and GD1a induces the production of anti-GM1 and anti-GD1a antibodies, and the development of Guillain-Barré syndrome. Complexes of two different gangliosides form new molecular shapes capable of enhancing recognition by anti-ganglioside antibodies. To test the hypothesis that the com...
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Molecular mimicry between host tissue structures and microbial components has been proposed as the pathogenic mechanism for triggering of autoimmune diseases by preceding infection. Recent studies stated that molecular mimicry as the causative mechanism remains unproven for most of the human diseases. Still, in the case of the peripheral neuropathy Guillain-Barré syndrome (GBS) this hypothesis ...
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GM(1)- and GD(1a)-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD(1a)-like mimicry. The presence of a few genes involved in LOS ganglio...
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ورودعنوان ژورنال:
- The Journal of infectious diseases
دوره 178 5 شماره
صفحات -
تاریخ انتشار 1998