The Significance of Porphyrinuria
نویسنده
چکیده
A pathologic increase in the amount of porphyrin excreted in the urine by patients with lead poisoning was first reported by Garrod (1) in 1892. Since then it has been generally assumed that this porphyrinuria is related in some way to the destruction of hemoglobin. Until recently there has been no means of testing the validity of this belief. Lately, however, the advance in knowledge concerning the chemistry of the porphyrins, and the development of methods for distinguishing one type from another, have provided a new approach towards an understanding of the underlying metabolic disorder responsible for the porphyrinuria of plumbism. The isomeric identity of the Type III coproporphyrin found in the urine in lead poisoning with the Type III protoporphyrin of hemoglobin has been demonstrated by Grotepass (2) and by Watson (3). The porphyrin in the urine in lead poisoning thus fundamentally differs from the Type I isomer which is the predominant type excreted in several other conditions associated with porphyrinuria. These facts justify the assumption that the porphyrinuria in lead poisoning is a consequence of some alteration in the metabolism of hemoglobin itself. In theory, it might originate from an altered synthesis of hemoglobin just as probably as from hemoglobin destruction; but owing to the traditional belief that the anemia in lead poisoning is hemolytic in nature, only the latter possibility has received any general attention until recently. The hypothesis that the coproporphyrin excreted in lead poisoning is a product of hemoglobin destruction requires, however, an additional corollary. In pathologic conditions as-
منابع مشابه
Clinical aspects of porphyrin measurement, other than lead poisoning.
Measurement of porphyrins and porphyrin precursors has clinical significance beyond the detection or confirmation of lead poisoning. The porphyric diseases of man are characterized by the presence of a specific clinical syndrome and demonstration of abnormal porphyrin excretion or accumulation in the tissues. In addition, porphyrins accumulate in other disorders that are unrelated to lead poiso...
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