Cohesin and the Maternal Age Effect

Pollen

Does cohesion fatigue play a role in the ‘maternal age effect’? The frequency of aneuploid conceptions in humans increases strikingly with maternal age, approaching 35% for women in their 40s. Remarkably, if studies of mouse oocytes are applicable to humans, it appears that the actual cohesin molecules that bind chromatids together in the oocytes of women may be decades old. In mammals, S phase...

Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2

BACKGROUND The growing trend for women to postpone childbearing has resulted in a dramatic increase in the incidence of trisomic pregnancies. Maternal age-related miscarriage and birth defects are predominantly a consequence of chromosome segregation errors during the first meiotic division (MI), which involves the segregation of replicated recombined homologous chromosomes. Despite the importa...

Age-Related Decrease of Meiotic Cohesins in Human Oocytes

Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic chromosomes. In mammalian oocytes, cohesion is established during the fetal stages and meiosis-sp...

Pnm-9: The Effect of Maternal Age (40 and Over 40 Years) on The Birth Weight, Mode of Delivery and Newborn

The effect of DHEA on apoptosis and cohesin levels in oocytes in aged mice.

Female fertility declines with age as the number of ovarian follicles decreases and aneuploidy increases. Degradation of the cohesin complex might be responsible for age-related aneuploidy. Dehydroepiandrosterone (DHEA) can improve the ovarian reserve and reduce the rate of aneuploidy, but the relationship between DHEA and cohesin levels in oocytes is still unknown. The aim of the current study...