PAVULON (pancuronium bromide) injection NOT FOR USE IN NEONATES CONTAINS BENZYL ALCOHOL THIS DRUG SHOULD BE ADMINISTERED BY ADEQUATELY TRAINED INDIVIDUALS FAMILIAR WITH ITS

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blocking agent chemically designated as the aminosteroid 2 ß, 16 ß dipiperidino-5α-androstane­ 3α, 17-ß diol diacetate dimethobromide. The structural formula is: PAVULON is supplied as a sterile, isotonic, nonpyrogenic solution for injection. Each mL contains 1 mg or 2 mg pancuronium bromide, 2 mg sodium acetate and 1% benzyl alcohol as preservative. The solution is adjusted to isotonicity with sodium chloride and to a pH of 4 with acetic acid and/or sodium hydroxide; water is used as the solvent. CLINICAL PHARMACOLOGY: PAVULON is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic pharmacological actions of this class of drugs (curariform). It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited and neuromuscular block is reversed by anticholinesterase agents such as pyridostigmine, neostigmine, and edrophonium. PAVULON is approximately 1/3 less potent than vecuronium and approximately 5 times as potent as d-tubocurarine; the duration of neuromuscular blockade produced by PAVULON is longer than that of vecuronium at initially equipotent doses. The ED95 (dose required to produce 95% suppression of muscle twitch response) is approximately

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تاریخ انتشار 2010