Sprint training normalizes Ca transients and SR function in postinfarction rat myocytes
نویسندگان
چکیده
LIAN-QIN ZHANG, XUE-QIAN ZHANG, YUK-CHOW NG, LAWRENCE I. ROTHBLUM, TIMOTHY I. MUSCH, RUSSELL L. MOORE, AND JOSEPH Y. CHEUNG Departments of Medicine, Pharmacology, and Cellular and Molecular Physiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania 17033; Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506; and Department of Kinesiology, University of Colorado, Boulder, Colorado 80309
منابع مشابه
Sprint training normalizes Ca(2+) transients and SR function in postinfarction rat myocytes.
Previous studies have shown that myocytes isolated from sedentary (Sed) rat hearts 3 wk after myocardial infarction (MI) undergo hypertrophy, exhibit altered intracellular Ca(2+) concentration ([Ca(2+)](i)) dynamics and abnormal contraction, and impaired sarcoplasmic reticulum (SR) function manifested as prolonged half-time of [Ca(2+)](i) decline. Because exercise training elicits positive adap...
متن کاملEffects of sprint training on contractility and [Ca(2+)](i) transients in adult rat myocytes.
The effects of 6-8 wk of high-intensity sprint training (HIST) on rat myocyte contractility and intracellular Ca(2+) concentration ([Ca(2+)](i)) transients were investigated. Compared with sedentary (Sed) myocytes, HIST induced a modest (5%) but significant (P < 0.0005) increase in cell length with no changes in cell width. In addition, the percentage of myosin heavy chain alpha-isoenzyme incre...
متن کاملEffects of sprint training on contractility and [Ca ]i transients in adult rat myocytes
Zhang, Xue-Qian, Jianliang Song, Lois L. Carl, Weixing Shi, Anwer Qureshi, Qiang Tian, and Joseph Y. Cheung. Effects of sprint training on contractility and [Ca2 ]i transients in adult rat myocytes. J Appl Physiol 93: 1310–1317, 2002. First published July 5, 2002; 10.1152/ japplphysiol.01071.2001.—The effects of 6–8 wk of highintensity sprint training (HIST) on rat myocyte contractility and int...
متن کاملSprint training restores normal contractility in postinfarction rat myocytes.
The significance of 6-8 wk of high-intensity sprint training (HIST) on contractile abnormalities of myocytes isolated from rat hearts with prior myocardial infarction (MI) was investigated. Compared with the sedentary (Sed) condition, HIST attenuated myocyte hypertrophy observed post-MI primarily by reducing cell lengths but not cell widths. At high extracellular Ca(2+) concentration (5 mM) and...
متن کاملSprint training improves contractility in postinfarction rat myocytes: role of Na+/Ca2+ exchange.
Previous studies in adult myocytes isolated from rat hearts 3-9 wk after myocardial infarction (MI) demonstrated abnormal contractility and decreased Na(+)/Ca(2+) exchanger (NCX1) activity. In addition, a program of high-intensity sprint training (HIST) instituted shortly after MI restored both contractility and NCX1 activity toward normal. The present study examined the hypotheses that reduced...
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