Degeneration of cingulum and fornix in a patient with traumatic brain injury: diffuse tensor tractography study.

Comparison of Limbic Regions FA Using Tractography-defined ROIs in AD and MCI

Introduction: The fornix and cingulum (limbic regions) are suspected of being affected by mild cognitive impairment (MCI) and Alzheimer Disease (AD). Recent studies have reported observable reductions in FA of the cingulum between normal and AD populations. Most studies resort to manual tracing of the anatomy in patient acquisition space. Objective isolation of the fornix and cingulum has remai...

Diffusion tensor tractography of traumatic diffuse axonal injury.

BACKGROUND Diffuse axonal injury is a common consequence of traumatic brain injury that frequently involves the parasagittal white matter, corpus callosum, and brainstem. OBJECTIVE To examine the potential of diffusion tensor tractography in detecting diffuse axonal injury at the acute stage of injury and predicting long-term functional outcome. DESIGN Tract-derived fiber variables were ana...

Quantitative diffusion tensor tractography of the cingulum: reproducibility, normal values and findings in traumatic brain injury

Recovery of an injured cingulum via an aberrant neural tract in a patient with traumatic brain injury

BACKGROUND We report on a patient who appeared to show recovery of an injured anterior cingulum via an aberrant neural tract between an injured cingulum and the basalis nucleus of Meynert following traumatic brain injury (TBI), which was demonstrated on diffusion tensor tractography (DTT). METHODS A 47-year-old male who had suffered a pedestrian traffic accident underwent conservative managem...

Longitudinal changes of structural connectivity in traumatic axonal injury.

OBJECTIVES To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome. METHODS The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postin...