A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins Running Title : Antitumoral activity of multivalent pseudopeptides

A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins.

Recent studies have implicated the involvement of cell surface forms of nucleolin in tumor growth. In this study, we investigated whether a synthetic ligand of cell-surface nucleolin known as N6L could exert antitumor activity. We found that N6L inhibits the anchorage-dependent and independent growth of tumor cell lines and that it also hampers angiogenesis. Additionally, we found that N6L is a...

Author's response to reviews Title: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type Authors:

Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs.

Various methods have been explored to enhance antibody-based cancer therapy. The use of multivalent antibodies or fragments against tumor antigens has generated a great deal of interest, as various cellular signals, including induction of apoptosis, inhibition of cell growth/survival, or internalization of the surface molecules, can be triggered or enhanced on extensive cross-linking of the tar...

New building blocks or dendritic pseudopeptides for metal chelating

Dendritic oligopeptides have been reported as useful building blocks for many interactions. Starting from hydrazine, we described an approach to create new dendritic pseudopeptides linked with biological systems, such as cell membrane, as chelate metal, Ni(2+)-nitrilotriacetic acid moieties which could target histidine rich peptides or proteins. Depending on the nature of these new chemical rec...

Social Anomia against the Backdrop of Misinformation/ Disinformation: A Cognitive Approach to the Multivalent Data in Cyberspace

The present study is an attempt to problematize the multivalent data in the cyberspace through the lenses of Wittgenstein’s analytic philosophy of language. Adopting this linguistic philosophy approach is aimed at exploring the dichotomous question of whether cyberspace is a possibility for social power or it is a contributory cause of communicative discontinuity and henceforth a possibility fo...