Muscle-specific overexpression of NCOAT, splice variant of O-GlcNAcase, induces skeletal muscle atrophy
نویسندگان
چکیده
Ping Huang, Shiuh-Rong Ho, Kai Wang, Bryan C. Roessler, Fengxue Zhang, Yong Hu, Damon B. Bowe, Jeffrey E. Kudlow, and Andrew J. Paterson Department of Pharmacology and Toxicology, Department of Cell Biology, Department of Physiology and Biophysics, Graduate Biomedical Sciences Program, and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama
منابع مشابه
Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy.
The protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification plays an important role in skeletal muscle development and physiological function. In this study, bitransgenic mice were generated that overexpressed NCOAT(GK), an O-GlcNAcase-inactive spliced variant of the O-GlcNAcase gene, specifically in skeletal muscle using the muscle creatine kinase promoter. Expression of the chimeric en...
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