Health Benefits of Resveratrol *
نویسندگان
چکیده
Resveratrol a polyphenolic phytoalexin possesses a variety of bioactivities associated with health promotion. Resveratrol is readily absorbed along with the other human dietary sources like peanuts, peanut butter, grapes, and red wine. The polyphenolic structure of resveratrol confers antioxidant activity and may reduce oxidant-induced apoptosis and low-density lipoprotein (LDL) oxidation. The cardioprotective activity of resveratrol is associated with the inhibition of platelet aggregation and LDL oxidation and the promotion of artery vasorelaxation. As a chemopreventing agent, resveratrol has been shown to inhibit tumor initiation, promotion, and progression, as well as inhibit the growth of cancerous cells through increased apoptosis and/or cell cycle blockage. Inflammatory processes are associated with the pathogenesis of many chronic diseases including heart disease and diabetes. In addition, the estrogenic activity of resveratrol may help in the prevention of post-menopausal osteophoresis. This review reveals potential health benefits and discusses the current preclinical studies of resveratrol.
منابع مشابه
اثرات ضد سرطانی رزوراترول بر سرطان پستان
Breast cancer is the most common cancer in women worldwide. Current cancer treatments have multiple side effects, including damage to healthy cells, drug resistance and disease recurrence. Therefore, new therapeutic strategies are needed to achieve fewer toxicity and side effects. Several studies suggest that phytochemicals could be considered as appropriate choices for cancer prevention and...
متن کاملBenefits of resveratrol in women's health.
Resveratrol and trans-resveratrol are powerful phytoestrogens, present in the skins of grapes and other plant foods and wine, which demonstrate a broad spectrum of pharmacological and therapeutic health benefits. Phytoestrogens are naturally occurring plant-derived nonsteroidal compounds that are functionally and structurally similar to steroidal estrogens, such as estradiol, produced by the bo...
متن کاملConstruction of artificial biosynthetic pathways for resveratrol glucoside derivatives.
Resveratrol, which is a polyphenolic antioxidant, is dose-dependent when used to provide health benefits, to enhance stress resistance, and to extend lifespans. However, even though resveratrol has therapeutic benefits, its clinical therapeutic effect is limited owing to its low oral bioavailability. An Escherichia coli system was developed that contains an artificial biosynthetic pathway that ...
متن کاملThe Sirtuin System: The Holy Grail of Resveratrol?
The oxidative stress theory has been associated with atherosclerosis and has prompted a multitude of studies to evaluate the effects of antioxidants on cardiovascular disease prevention. Resveratrol, a relatively new antioxidant has gained considerable curiosity. This polyphenol stilbene identified in grape skin, is believed to be the main component contributing to the anti-atherosclerotic bene...
متن کاملFinding a Target for Resveratrol
Despite resveratrol's well-documented health benefits, its mechanism of action remains controversial. In particular, the direct molecular target of resveratrol has been elusive. Park et al. now show that resveratrol directly inhibits cAMP-dependent phosphodiesterases, triggering a cascade of events that converge on the important energy-sensing metabolic regulators AMPK, SIRT1, and PGC-1α.
متن کامل