Studying Protein Folding Using Motion Planning Techniques
نویسندگان
چکیده
The goal of this project is to use PRM (probabilistic roadmap) methods to study protein folding. Given a goal (native fold) configuration, we are able to construct a roadmap and derive a set of possible paths for the protein to follow. To do so, we model proteins as multi-link treelike robots with many degrees of freedom. Our work concentrates on improving our techniques for studying the potential landscape of folding pathways. We propose to focus our energy on developing methods that find natural groupings of paths. 1This research supported in part by NSF CAREER Award CCR-9624315, NSF Grants IIS-9619850, ACI9872126, EIA-9975018, EIA-9805823, and EIA-9810937, DOE ASCI ASAP Level 2 Grant B347886, and a HewlettPackard Equipment Grant. Susan Lin supported by the NSF through the CRA-W DMP program.
منابع مشابه
A Motion Planning Approach to Folding: From Paper Craft to Protein Structure Prediction
From Paper Craft to Protein Structure Prediction Guang Song Nancy M. Amato [email protected] [email protected] Technical Report 00-001 Department of Computer Science Texas A&M University January 17, 2000 Abstract In this paper, we present a framework for studying folding problems from a motion planning perspective. In particular, all folding objects are modeled as tree-like multi-link articulat...
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