Targeted Disruption of Stat3 Signaling Inhibits Tumor Growth and Brain Metastases by Caveolin-1 Upregulation
نویسندگان
چکیده
Departments of Neurosurgery, Pathology, Neuro-Oncology, and Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA; Women’s Cancer Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA; Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan; and Program in Cancer Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas, USA
منابع مشابه
Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition.
Stat3 activation has been implicated as an important driver of brain metastasis in breast cancer, but the critical targets of Stat3 in this process are yet to be fully defined. In this study, we identified the lipid raft organizing protein Caveolin-1 (Cav-1) as a critical genetic target of Stat3 in this process. In human breast cancers, we found that activated Stat3 correlated with attenuation ...
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