Differences in ovarian function parameters between Chinese and Caucasian oocyte donors: do they offer an explanation for lower IVF pregnancy rates in Chinese women?
نویسندگان
چکیده
BACKGROUND IVF outcomes in Chinese women are inferior to those of Caucasian patients. Reflecting prematurely diminished ovarian function, women with elevated age-specific baseline (b-) FSH levels are designated to suffer from premature ovarian aging (POA). We investigated if the prevalence of POA differs between these two ethnic populations. METHODS We compared patient characteristics and first IVF cycle outcomes in 29 consecutive, Caucasian and 17 Asian-Chinese oocyte donors. POA was diagnosed in a donor if her b-FSH levels exceeded the 95% confidence interval (CI) for her age group. RESULTS There was no age difference between Chinese and Caucasian groups (26.2 +/- 4.9 versus 25.7 +/- 3.1 years, respectively). Chinese women demonstrated, however, a higher cycle cancellation rate (5/17, 29.4%), either before cycle start or during stimulation (0/29; relative risk 1.42, 95% CI 1.04-1.9; P < 0.01), fewer oocytes per initiated cycle (9.3 +/- 9.7 versus 15.3 +/- 7.1, respectively; P < 0.05) (difference disappeared for only cycles that reached retrieval) and higher b-FSH levels (7.5 +/- 1.9 versus 5.1 +/- 1.7 mIU/ml, respectively; P = 0.004). Nine out of 17 (53%) of Chinese and only 1/26 (4%) of Caucasian donors met b-FSH level criteria for a presumptive POA diagnosis. Their odds of meeting POA criteria were approximately 30-times greater (odds ratio 31.5; 95% CI 3.5-18.7; P < 0.0001). CONCLUSIONS These data suggest a possible explanation for lower IVF pregnancy rates in Chinese women. Preceding treatment, Chinese women at all ages should be carefully investigated to detect occult POA. Ethnicity may have to be considered an additional outcome variable in fertility studies.
منابع مشابه
I-25: Management of Hydrosalpinx in ART
Hydrosalpinx, is one of the severe manifestations of tubal disease, is associated with significantly lower implantation and pregnancy rates, increased spontaneous abortion and ectopic pregnancy.This condition is usually due to PID but may also result from peritonitis of any cause or tubal damage from previous surgery.The mechanism for poor outcome in patients undergoing IVF is not yet clear. Ma...
متن کاملOvarian response prediction in controlled ovarian stimulation for IVF using anti-Müllerian hormone in Chinese women
The predictive value of anti-Müllerian hormone (AMH) in Chinese women undergoing in vitro fertilization (IVF) treatment is data deficient. To determine the attributes of AMH in IVF, oocyte yield, cycle cancellation, and pregnancy outcomes were analyzed. All patients initiating their first IVF cycle with gonadotropin-releasing hormone agonist treatment in our center from October 2013 through Dec...
متن کاملO-24: Single Oocyte Secretoma Mapping by NMR-Metabolomics Technology: A Non-Invasive Strategy to Select The Best Oocytes to Fertilize Avoiding Supernumerary Embryos and Increasing Take- Home-Baby-Rate after IVF
Background Current strategies based on random selection of MII-oocytes to fertilize appear unsatisfactory in selecting the best number and the most vital oocytes to fertilize especially in poor responder women in which “chronological age” does not mismatch with “biological age”. The metabolomics- profiling approach, evaluating the final products of cell regulatory process (genome/transcriptome/...
متن کاملA Comparison of Outcomes from IVF Cycles Stimulated with either Recombinant Luteinizing Hormone or Human Menopausal Gonadotropins in Subjects Treated with Long Gonadotropin Releasing Hormone Agonist Protocols, a Retrospective Analysis.
Objective The objective of this study is to compare rates of pregnancy and IVF parameters in subjects who were stimulated with follicle stimulating hormone (FSH) plus either recombinant human luteinizing hormone (r-LH) or human menopausal gonadotropins (hMG), in long gonadotropin releasing hormone (GnRH) agonist IVF protocols. MaterialsAndMethods This is a cohort study of patients undergoing IV...
متن کاملO-19: Fertilization Rates Are Improved after IVF if The Corona Radiata Is Left Intact in Vitrified-Warmed Human Oocytes
Background: Before human MII oocytes are vitrified they are usually denuded from their cumulus cells. In this study we wanted to investigate the effects of an intact corona radiata on the vitrification and fertilization of human oocytes. Materials and Methods: The study comprised two different parts. In Part 1, 36 MII stage oocytes, from 6 patients, were randomly assigned into a control group, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Human reproduction
دوره 22 11 شماره
صفحات -
تاریخ انتشار 2007