Schizophrenia Forum - Print News
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23 May 2008. Microdeletions at chromosome 22q11 that are associated with schizophrenia in humans alter the production of gene-regulating microRNAs in mice, according to a new report in the May 11 issue of Nature Genetics. The work, from Joseph Gogos and Maria Karayiorgou of Columbia University, New York, zeroes in on deletion of the microRNA-processing gene Dgcr8 as responsible for changes in miRNA expression and contributing to the behavioral and neuronal phenotypes of 22q11 deletion in mice. The work is the first time that microRNAs have been implicated in cognitive dysfunction associated with schizophrenia, and may provide a new handhold on the complex molecular basis of the disease.
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Schizophrenia Forum - Print News
4 November 2005. There is now overwhelming evidence that genetic inheritance plays a major role in susceptibility to schizophrenia. And though no schizophrenia genes have yet been confirmed, there are plenty of candidates. Multiple lines of evidence, for example, suggest that a region in the small arm of chromosome 22 (22q11.2) might confer susceptibility to the disease. Two recent Nature Neuro...
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30 January 2004. Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that features hallucinations—an occasional feature of AD—and obvious deficits in working memory? Here, then, is such a peek: A paper in Nature Genetics, wherein ...
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21 November 2006. The enzyme AKT1 has been implicated in both schizophrenia and bipolar disorder. A new study in the November 7 issue of PNAS finds that a mouse lacking the gene for AKT1 shows subtle alterations of neuronal morphology in prefrontal cortex, as well as deficits in working memory. Joseph Gogos and Maria Karayiorgou of Columbia University in New York City also report that the absen...
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7 January 2009. It was reported several years ago that the gene for Nogo-66 receptor 1 (NGR, or RTN4R), located in the chromosome 22q11 region, may influence genetic predisposition to schizophrenia (Liu et al., 2002). Stephen Strittmatter and colleagues of Yale University in New Haven, Connecticut, find support for this association in a study published in the December 3 issue of the Journal of ...
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30 May 2008. In the latest of a flurry of recent papers examining the role of copy number variations (CNVs) in schizophrenia, researchers report a strong association between de novo CNVs and the sporadic, or nonfamilial, form of the disorder. The paper is part of another flurry as well, being the third major paper this month from the Columbia University groups led by Maria Karayiorgou and Josep...
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