Genome instability: McClintock revisited
نویسنده
چکیده
Recent studies in yeast have shed light on the molecular mechanisms by which telomere dysfunction leads to chromosome fusions. Furthermore, examination of the consequences of telomerase loss in mice suggests that only a few critically short telomeres may be sufficient to promote genomic instability.
منابع مشابه
Barbara McClintock on Defining the Unstable Genome.
It is with this prescient statement that Barbara McClintock began the discussion of her classic 1953 GENETICS article describing how so-called “extragenic” components, now known as transposons, could alter the function of nearby genes. Precisely 30 years later she would be the sole winner of the Nobel Prize in Physiology or Medicine for her scrupulous studies of unexpected phenotypic changes sh...
متن کاملTransposable elements: Barbara McClintock and early experiments in maize In 1938 Marcus Rhodes provided the first genetic description of an unstable mutation, an allele of a gene required for the production of pigment in maize
In 1938 Marcus Rhodes provided the first genetic description of an unstable mutation, an allele of a gene required for the production of pigment in maize. This instability resulted in a variegated phenotype. Variegation describes irregular patterns of pigmentation and reflects changes in the expression of genes that control pigment production. Rhodes defined two genes required for this instabil...
متن کاملMcClintock: An Integrated Pipeline for Detecting Transposable Element Insertions in Whole-Genome Shotgun Sequencing Data
Transposable element (TE) insertions are among the most challenging types of variants to detect in genomic data because of their repetitive nature and complex mechanisms of replication . Nevertheless, the recent availability of large resequencing data sets has spurred the development of many new methods to detect TE insertions in whole-genome shotgun sequences. Here we report an integrated bioi...
متن کاملTrasposable Elements: P Elements
In 1938 Marcus Rhodes provided the first genetic description of an unstable mutation, an allele of a gene required for the production of pigment in maize. This instability resulted in a variegated phenotype. Variegation describes irregular patterns of pigmentation and reflects changes in the expression of genes that control pigment production. Rhodes defined two genes required for this instabil...
متن کاملThe origin of an unstable locus in maize.
I N maize many unst(ab1e gene loci can, upon analysis, be ascribed to specific mutable systems. Often these systems consist of two units: a controlling element, such as Ds or Z, which responds to a regulatory element, Ac or En, respectively (PETERSON 1965). In addition, in cultures known to contain elements of a mutable system, such1 as Ac-Ds (MCCLINTOCK 1950, 1951) or En-Z (PETERSON 1960, 1961...
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ورودعنوان ژورنال:
- Current Biology
دوره 11 شماره
صفحات -
تاریخ انتشار 2001