New Developments for Parkinson’s Therapy with Comt Inhibitors

نویسندگان

  • Heinz Reichmann
  • Werner Poewe
  • Georg Ebersbach
  • Thomas Müller
چکیده

Disclosure: Prof Heinz Reichmann received research grants and compensation for his involvement on advisory boards and lectures from Abbott, Abbvie, Bayer Health Care, BIAL, Boehringer/Ingelheim, Brittania, Cephalon, Desitin, GSK, Lundbeck, Medtronic, Merck-Serono, Novartis, Orion, Pfizer, TEVA, UCB Pharma, Valeant, and Zambon. Prof Werner Poewe has received honoraria for lectures and consultancy fees in relation to clinical drug development programmes for Parkinson’s disease from AbbVie, Allergan, AstraZeneca, BIAL, Boehringer Ingelheim, Boston Scientific, GlaxoSmithKline, Ipsen, Lundbeck, Medtronic, MSD, Merck-Serono, Merz Pharmaceuticals, Novartis, Orion Pharma, Teva, UCB, and Zambon. He also received royalties from Thieme, Wiley Blackwell, Oxford University Press, and Cambridge University Press. Prof Georg Ebersbach has received honoraria for consulting from AOK Nordost and in his capacity as advisor for AbbVie Pharma, Grünenthal Pharma, and UCB Pharma. Furthermore, he received honoraria for speaker engagements from AbbVie Pharma, BIAL Pharma, Britannia Pharma, Desitin Pharma, Grünenthal Pharma, Licher GmbH, Mundipharma, TEVA Pharma, UCB Pharma, and Zambon Pharma. Prof Ebersback also receives royalties from Kohlhammer Verlag. Prof Thomas Müller has received honoraria from BIAL. Acknowledgements: Writing assistance provided by Dr Juliane Moloney, ApotheCom, London, UK. Support: Jan Jastorff translated the transcript of the presentation and BIAL/Basilio Hernandes carried out a review for medical accuracy. The satellite symposium and the publication of this article were funded by BIAL-Portela & Ca., S.A. The views and opinions expressed are those of the authors and not necessarily of BIAL-Portela & Ca., S.A. Citation: EMJ Neurol. 2017;5[Suppl 1]:2-10.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Spotlight on opicapone as an adjunct to levodopa in Parkinson’s disease: design, development and potential place in therapy

Parkinson's disease (PD) is a progressive, chronic, neurodegenerative disease characterized by rigidity, tremor, bradykinesia and postural instability secondary to dopaminergic deficit in the nigrostriatal system. Currently, disease-modifying therapies are not available, and levodopa (LD) treatment remains the gold standard for controlling motor and nonmotor symptoms of the disease. LD is exten...

متن کامل

Catechol-O-Methyltransferase in Parkinson’s Disease

The introduction of levodopa therapy for Parkinson’s disease (PD), initially by Birkmayer and colleagues in 1961 and Barbeau and colleagues in 1962, and in its ultimately successful form by Cotzias and colleagues in 1967, still represents the defining landmark in the treatment of PD (1–3). This dramatic advance was preceded by methodical basic laboratory research in the late 1950s and early 196...

متن کامل

Catechol-O-methyltransferase and Parkinson's disease.

Parkinson's disease (PD) is one of the main causes of neurological disability in the elderly. Levodopa is the gold standard for treating this disease, but chronic levodopa therapy is complicated by motor fluctuation and dyskinesia. The catechol-O-methyltransferase (COMT) inhibitors represent a new class of antiparkinsonian drugs. When coadministered with levodopa/decarboxylase inhibitor, 2 COMT...

متن کامل

Utility of tolcapone in fluctuating Parkinson’s disease

Fluctuating Parkinson's disease (PD) represents a clinical management challenge. The primary utility of levodopa in patients with PD is moderated by the "wearing off" phenomena seen with long-term use. COMT inhibitors slow down the rapid metabolism of levodopa, resulting in a more-sustained response to dopaminergic therapy. Tolcapone is a selective, reversible catechol-O-methyltransferase (COMT...

متن کامل

COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson’s disease (PD): relevance for motor and non-motor features

Levodopa is the most effective treatment in Parkinson's disease and the association with COMT inhibitors widens its plasma bioavailability and effectiveness. Tolcapone is a potent COMT inhibitor whose utilization in PD is limited due to safety concerns on liver toxicity. However, recent data indicate that if liver function is actively monitored, tolerability is no worse than other currently ava...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017