Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.

نویسندگان

  • J W Tunnell
  • A E Desjardins
  • L Galindo
  • I Georgakoudi
  • S A McGee
  • J Mirkovic
  • M G Mueller
  • J Nazemi
  • F T Nguyen
  • A Wax
  • Q Zhang
  • R R Dasari
  • M S Feld
چکیده

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

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عنوان ژورنال:
  • Technology in cancer research & treatment

دوره 2 6  شماره 

صفحات  -

تاریخ انتشار 2003