In vivo antibacterial activity of MRX-I, a new oxazolidinone.
نویسندگان
چکیده
MRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). In this study, the in vivo efficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 58 4 شماره
صفحات -
تاریخ انتشار 2014