Keeping Up With the Clock
نویسندگان
چکیده
Estimates of obesity prevalence based on the 2013 to 2014 National Health and Nutrition Examination Survey average almost 40%, corresponding to a 7% increase from the 1999 to 2000 cycle. Similar alarming trajectories are reported worldwide, along with increasing concerns for related health risks. The traditional concept that obesity results from a mere imbalance between energy intake and energy consumption has evolved to incorporate novel modulating factors that may be targeted to develop preventative strategies. One such example is the potential role of disruption of circadian rhythms. In this brief review, the physiology of circadian control of body weight and metabolism and the implications of altered circadian rhythms for obesity risk in humans will be discussed, together with potential countermeasures that may mitigate such consequences. The focus is on evidence accumulated from human studies. For a comprehensive review on the molecular mechanisms underlying the clock in metabolism and obesity, we direct the interested readers to Eckel-Mahan and Sassone-Corsi.
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