Hormone replacement therapy for a young woman with cervical sarcomatoid squamous cell carcinoma

Cervical sarcomatoid squamous cell carcinoma (SSCC) is an extremely rare malignancy. We report the case of a young woman with cervical SSCC who experienced peri-menopausal syndrome following treatment, and present our evaluation of the considerations relating to hormone replacement therapy (HRT) in this case. A 24-yearold Chinese woman with SSCC underwent radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. Following surgery, she received radiation therapy, chemotherapy and lymphocyte immunotherapy; and developed severe menopausal symptoms. After assessing for the pathological type of carcinoma, hormone receptor status and disease stage, we performed HRT for this young woman. During the two years of follow-up, she remained cancer-free without post-menopausal symptoms. We conclude that HRT following surgery may be appropriate in certain young women with cervical sarcomatoid carcinoma to enhance their quality of life.