DNase Sda1 Provides Selection Pressure for a Genetic and Phenotypic Switch Promoting Invasive Group A Streptococcal Infection
نویسندگان
چکیده
oC in human p lasma. 5448AP accumulates significantly higher levels of surface plasmin activity (n = 3; mean ± SD) compared to 5448AP∆ska and 5448AP∆emm1. Asterisk indicates statistically significant difference from 5448AP, where P < 0.05. DNase Sda1 Provides Selection Pressure for a Genetic and Phenotyp ic Switch Promoting Invasive Group A Streptococcal Infection M.J. W alker, A. Hollands, M.L. Sanderson-Smith, J.N. Cole, J.K. Kirk, A. Henningham, J.D. McArthur, K. Dinkla, R.K. Aziz, R.G. Kansal, A. J. Simpson, J.T. Buchanan, G.S. Chhatwal, M. Kotb, V. Nizet
منابع مشابه
Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370.
The resurgence of invasive disease caused by Streptococcus pyogenes (group A Streptococcus [GAS]) in the past 30 years has paralleled the emergence and global dissemination of the highly virulent M1T1 clone. The GAS M1T1 clone has diverged from the ancestral M1 serotype by horizontal acquisition of two unique bacteriophages, encoding the potent DNase Sda1/SdaD2 and the superantigen SpeA, respec...
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