Retreatment of Serofast Early Syphilis Patients With Benzathine Penicillin
نویسندگان
چکیده
Arlene C. Seña, Mark Wolff, Frieda Behets, Kathleen Van Damme, David H. Martin, Peter Leone, Linda McNeil, and Edward W. Hook Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill; EMMES Corporation, Rockville, Maryland; Department of Epidemiology, University of North Carolina at Madagascar, Antananarivo; Department of Medicine, Louisiana State University, New Orleans; FHI 360, Research Triangle Park, North Carolina; and Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham
منابع مشابه
Serological response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.
Background Some syphilitic patients remain in a serologically positive state after the recommended therapy. Although we often retreat patients in clinical practice, the optimal treatment protocol remains uncertain due to the paucity of data regarding serological response to retreatment and long-term outcomes. Methods We examined rapid plasma reagin serological test results of 70 serofast earl...
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IMPORTANCE The incidence of syphilis in the United States is increasing; it is estimated that more than 55,000 new infections will occur in 2014. Treatment regimens are controversial, especially in specific populations, and assessing treatment response based on serology remains a challenge. OBJECTIVE To review evidence regarding penicillin and nonpenicillin regimens, implications of the "sero...
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BACKGROUND Syphilis continues to be a common sexually transmitted infection, despite the availability of inexpensive and effective treatment. Infection in human immunodeficiency virus (HIV)-discordant couples is important because syphilis increases the risk of HIV acquisition. Current US treatment guidelines recommend 1 dose of benzathine penicillin for early syphilis, irrespective of HIV statu...
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INTRODUCTION Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with benzathine penicillin compared with doxycycline or tetracycline. METHODOLOGY We examined rapid plasma regain (RPR) serological test results of...
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BACKGROUND While doxycycline is recommended as an alternative treatment of syphilis in patients with penicillin allergy or intolerance, clinical studies to compare serological response to doxycycline versus benzathine penicillin in treatment of early syphilis among HIV-infected patients remain sparse. METHODS We retrospectively reviewed the medical records of HIV-infected patients with early ...
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