The MABA approach: a new option to improve bronchodilator therapy.
نویسندگان
چکیده
Affiliations: Unit of Respiratory Clinical Pharmacology, Dept of System Medicine, University of Rome Tor Vergata, Rome, Italy. Unidad Medico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio, Seville, CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, and Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Gregorio Marañón, Madrid, Spain.
منابع مشابه
Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.
The objective of the present studies was to characterize the pharmacologic properties of GSK-961081 [TD-5959; (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl) piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate], a novel first-in-class inhaled bifunctional compound possessing both muscarinic antagonist (MA) and β2-ad...
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The objective of the present studies was to characterize the pharmacologic properties of GSK-961081 [TD-5959; (R)-1-(3-((2chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl) piperidin-4-yl [1,19-biphenyl]-2-ylcarbamate], a novel first-in-class inhaled bifunctional compound possessing both muscarinic antagonist (MA) and b2-ad...
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 42 4 شماره
صفحات -
تاریخ انتشار 2013