Microbial Conversion of Anthracyclinones to Daunomycin
نویسندگان
چکیده
Baumycin-negative mutants of Streptomyces coeruleorubidus ME130-A4 do not convert daunomycinone to daunomycin and baumycins. They biosynthesize daunomycin from aklavinone and e-rhodomycinone, indicating the glycosidation of the aglycone before the synthesis of daunomycinone. The biosynthetic pathway from a-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthracyclines, which are presumed to be intermediates.
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