Enzyme activities of jejunal mucosa in experimental blind loop syndrome of rat.

Decreased activities of jejunal mucosal enzymes, i.e. lactase, sucrase, maltase and gamma-glutamyl transpeptidase were found in rats with experimental blind loop syndrome. The peroral administration of Kanamycin induced both reduction in fecal fat excretion and restoration of enzyme activities in rats with the blind loop syndrome. Similar effects of Kanamycin on fecal fat excretion and jejunal mucosal enzyme activities were also recognized in unoperated rats. There was an inverse relationship between fecal fat excretion and activities of those enzymes which are mainly located in the brush border of the enterocyte. From these results, significance of jejunal brush border enzymes in the blind loop syndrome was discussed.