Growth factors and lymphokines: modulators of cholinergic neuronal activity.
نویسندگان
چکیده
It is well known that various markers of the cholinergic synapse are altered in Alzheimer's Disease. Much interest is currently focussing on the evaluation of the possible efficacy of certain growth factors, especially nerve growth factor (NGF), to reduce or reverse cholinergic neuronal losses. Here we report that other growth factors (epidermal growth factor and insulin-like growth factor I) and a lymphokine, interleukin-2, are able to block acetylcholine release in the rat hippocampus. This suggests that while certain growth factors like NGF may have positive effects on the cholinergic neuron, others may act as "negative" factors on this neuronal population.
منابع مشابه
Induction of Bone Marrow Stromal Cells into Cholinergic-Like Cells by Nerve Growth Factor
Background: Bone marrow stromal cells (BMSC) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. However, the transdifferentiation of BMSC into cholinergic phenotype requires more investigation. Methods: BMSC were isolated from adult rats, pre-induced with β-mercaptoethanol (BME) and followed by nerve growth factor (NGF) indu...
متن کاملEffect of Trans-cinnamic Acid on Cognitive Deficit, Cell Density of CA1/CA3 Regions, and Cholinergic Activity of Hippocampus in Trimethylettin Model of Alzheimer's Disease
Introduction: Trimethyltin (TMT) intoxication is associated with damage to the cholinergic system in the hippocampus. The aim of this study was to evaluate the effect of trans-cinnamic acid on cognitive deficit and cell damage in CA1/CA3 regions of the hippocampus, as well as measure the activity of acetyl choline esterase (AChE) in the hippocampus of a rat model of Alzheimer’s disease (AD). Ma...
متن کاملVenom based neural modulators
Different types of neuronal nicotinic acetylcholine receptors (nAChRs) are expected to occur in vivo, most structure-activity relationship studies have been carried out for just a few neuronal subtypes. The present review enlightens current aspects of venom modulators of nAChRs. Important electronic databases such as PubMed or Google scholar were explored for the collection of latest studies in...
متن کاملThe role of muscarnic cholinergic receptor of the bed nucleus of stria terminalis on cardiovascular response and baroreflex modulation in rat.
Introduction: The bed nucleus of the stria terminalis (BST) is a limbic structure which is involved in cardiovascular regulation and baroreflex modulation. The presence of cholinergic synaptic terminalis with high level of muscarinic receptors in the BST has been demonstrated. This study was performed to find the role of the cholinergic muscarinic receptor in cardiovascular response and baro...
متن کاملVarenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease
Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
دوره 18 3 Suppl شماره
صفحات -
تاریخ انتشار 1991