Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits.

Regular Article THROMBOSIS AND HEMOSTASIS Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

• Antisense oligonucleotides reduce levels of target hepatic mRNA and protein and decrease clotting activity in rabbits. • Selective depletion of factors XI and XII in rabbits attenuates catheter thrombosis, whereas factor VII depletion does not. Central venous catheter thrombosis can cause venous obstruction and pulmonary embolism. To determine the extent to which catheter thrombosis is trigge...

Making (anti)sense of factor XI in thrombosis.

Inhibiting thrombosis without inducing bleeding is the holy grail of anticoagulant therapy. Currently, there are no commercially available anticoagulants that achieve this goal. Although many antithrombotic agents improve survival by interfering with vessel thrombosis, this protection always comes at the cost of an increased risk of bleeding. The observation that inhibitors of thrombosis increa...

Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.

OBJECTIVE Coagulation factor XI is proposed as therapeutic target for anticoagulation. However, it is still unclear whether the antithrombotic properties of factor XI inhibitors influence atherosclerotic disease and atherothrombosis. Our aim is to investigate whether factor XI antisense oligonucleotides could prevent thrombus formation on acutely ruptured atherosclerotic plaques. APPROACH AND...

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding Short Title: Antisense suppression of PKK and fXII expression in mice

Thrombosis Prevention without Anticoagulation

The ultimate goal for hematologists, cardiologists, and vascular medicine physicians is to find agents that prevent thrombosis without creating defects in hemostasis (the cessation of bleeding). To a great extent, this notion was considered an impossible dream. However, recent advances in understanding of the plasma contact activation, kallikrein/kinin, renin angiotensin, and other vasoregulato...