An trans-retinoic acid in the treatment of promyelocytic leukaemia - a case report
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چکیده
Acute Promyelocytic Leukaemi.a (APML) is an uncommon type of acute non-lymphocytic leukaemia (ANLL)l. Treatment of APML is associated with significant mortality and morbidity. Ten to twenty per cent of the patients die early of fatal haemorrhage resulting from coagulopathy and sepsis. An alternative approach to the treatment of APML has centered on the use of differentiating agents to induce remission. Recent therapeutic trials confirm that all-trans retinoic acid is a safe and highly effective agent for inducing complete remission in AP.MIP·4.5. We report a child with relapsed APML who failed reinduction with conventional chemotherapy but responded to all trans-retinoic acid.
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