CALL FOR PAPERS Control Mechanisms of Renin Synthesis and Release: A 21st Century Perspective Renal nerves and nNOS: roles in natriuresis of acute isovolumetric sodium loading in conscious rats
نویسندگان
چکیده
Elżbieta Kompanowska-Jezierska, Helle Wolff, Marta Kuczeriszka, Jan B. Gramsbergen, Agnieszka Walkowska, Edward J. Johns, and Peter Bie Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark; Laboratory of Renal and Body Fluid Physiology, M. Mossakowski Medical Research Centre of the Polish Academy of Sciences, Warsaw, Poland; Department of Anatomy and Neurobiology, University of Southern Denmark, Odense, Denmark; and Department of Physiology, University College Cork, Cork, Republic of Ireland
منابع مشابه
Renal nerves and nNOS: roles in natriuresis of acute isovolumetric sodium loading in conscious rats.
It was hypothesized that renal sympathetic nerve activity (RSNA) and neuronal nitric oxide synthase (nNOS) are involved in the acute inhibition of renin secretion and the natriuresis following slow NaCl loading (NaLoad) and that RSNA participates in the regulation of arterial blood pressure (MABP). This was tested by NaLoad after chronic renal denervation with and without inhibition of nNOS by ...
متن کاملCALL FOR PAPERS Control Mechanisms of Renin Synthesis and Release: A 21st Century Perspective Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium
Kjolby M, Bie P. Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium. Am J Physiol Regul Integr Comp Physiol 294: R17–R25, 2008. First published November 7, 2007; doi:10.1152/ajpregu.00435.2007.—Responses to acute sodium loading depend on the load and on the level of chronic sodium intake. To ...
متن کاملCALL FOR PAPERS Control Mechanisms of Renin Synthesis and Release: A 21st Century Perspective NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats
Siragy HM, Inagami T, Carey RM. NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats. Am J Physiol Regul Integr Comp Physiol 293: R1461–R1467, 2007. First published August 1, 2007; doi:10.1152/ajpregu.00014.2007.—We hypothesized that angiotensin subtype-2 receptor (AT2R) inhibits renal renin biosynthesis in young rats via nitric oxide (NO). We monitored chan...
متن کاملNormotensive sodium loading in conscious dogs: regulation of renin secretion during -receptor blockade
Bie P, Mølstrøm S, Wamberg S. Normotensive sodium loading in conscious dogs: regulation of renin secretion during -receptor blockade. Am J Physiol Regul Integr Comp Physiol 296: R428–R435, 2009. First published December 10, 2008; doi:10.1152/ajpregu.90753.2008.—Renin secretion is regulated in part by renal nerves operating through 1-receptors of the renal juxtaglomerular cells. Slow sodium load...
متن کاملDietary sodium loading increases arterial pressure in afferent renal-denervated rats.
In rats fed high sodium diet, increasing renal pelvic pressure > or =3 mm Hg activates renal mechanosensory nerves, resulting in a renorenal reflex-induced increase in urinary sodium excretion. The low activation threshold of the renal mechanosensory nerves suggests a role for natriuretic renorenal reflexes in the regulation of arterial pressure and sodium balance. If so, interruption of the af...
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