In silico Analysis of Binding Interaction of Antiepileptic Drugs with GABA Receptor Associated Protein of Caenorhabditis elegans
نویسنده
چکیده
Malfunctioning of synaptic vesicle in the absence of some essential regulatory proteins causes a significant decrease in the level of neurotransmitters like gamma-amino butyric acid (GABA) leading to epilepsy. In the present work, GABA receptor associated protein (GABARAP), being the major inhibitory neurotransmitter receptor from C. elegans, is investigated for its efficacy with various antiepileptic drugs. These drugs interact with the binding site of GABA receptor and regain the normal level of the inhibitory neurotransmitter, GABA. These inhibitors play a crucial role in controlling the expression of the neurotransmitter receptor at the postsynaptic membrane. Our results shows that out of the various drugs docked at the binding site, Vigabatrin and Pregablin came up with the highest score thereby proving them to be effective in the treatment of the neurological disorder.
منابع مشابه
In silico Analysis of Binding Interaction of Antiepileptic Drugs with GABA Receptor Associated Protein of Caenorhabditis elegansIn silico Analysis of Binding Interaction of Antiepileptic Drugs with GABA Receptor Associated Protein of Caenorhabditis elegans
Malfunctioning of synaptic vesicle in the absence of some essential regulatory proteins causes a significant decrease in the level of neurotransmitters like gamma-amino butyric acid (GABA) leading to epilepsy. In the present work, GABA receptor associated protein (GABARAP), being the major inhibitory neurotransmitter receptor from C. elegans, is investigated for its efficacy with various antiep...
متن کاملIn Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier
Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation. The BDNF deficiency is correlated with various diseases and affects aging and miscellaneous. In the present study we aimed to design a chimeric LAMP-BDN...
متن کاملIn silico Study of Toll-Like Receptor 4 Binding Site of FimH from Uropathogenic Escherichia coli
Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and acquired immunity. FimH adhesin, a minor component of type 1 fimbriae encoded by Uropathogenic Escherichia coli (UPEC) is a PAMP of TLR4 tha...
متن کاملModulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs
The microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electrosho...
متن کاملGABA is dispensable for the formation of junctional GABA receptor clusters in Caenorhabditis elegans.
At GABAergic synapses, GABA receptors form high-density clusters opposite GABA release sites. Whether GABA release per se plays a role in the formation of GABA receptor clusters remains uncertain. To address this question in vivo, we characterized GABA receptor clustering in the nematode Caenorhabditis elegans. In C. elegans, body wall muscles receive excitatory inputs from cholinergic motor ne...
متن کامل