Myenteric plexus in Hirschsprung's disease.

The absence of ganglion cells and the presence of abnormal bundles of unmyelinated fibres in the affected segment in Hirschsprung's disease was first well described by Whitehouse and Kernohan (f948). However, previous authors who have studied this problem have used standard transverse sections of the gut to demonstrate the abnormalities but these give a very inadequate view of the plexus which is a complicated network lying parallel to the gut wall. If the intestine is cut in this plane the plexus can be viewed en face which gives a much better picture of the anatomy and pathology.