Menopausal hormone therapy and national time trends in mortality: cautions regarding causal inference.

877 Validity, cut-points, and minimally important differences for two hot fl ash-related daily interference scales Janet S. Carpenter, PhD, RN, FAAN, Giorgos Bakoyannis, PhD, Julie L. Otte, PhD, RN OCN, Chen X. Chen, PhD, RN, Kevin L. Rand, PhD, Nancy Woods, PhD, RN, FAAN, Katherine Newton, PhD, Hadine Joffe, MD, MSc, JoAnn E. Manson, MD, DrPH, Ellen W. Freeman, PhD, and Katherine A. Guthrie, PhD This paper describes how the 10-item Hot Flash Related Daily Interference Scale was condensed to create the psychometrically strong 3-item Hot Flash Interference scale to measure the impact of vasomotor symptoms on a woman’s life. Cutpoints and minimally important differences for both scales are provided. Menopause