Skin sterols. VIII. Effects of carcinogens, co-carcinogens, and of certain hyperplastic agents.
نویسندگان
چکیده
S Published with the approval of the director of the Wiscon sin Agricultural Experiment Station. Supported in part by the Jonathan Bowman fund, and by grant C-2177, National Insti tutes of Health, US. Public Health Service. Presented in part before the American Society of BiologicalChemists, Atlantic City, April 13, 1954 (Fed. Proc., 13:238, 1954). t PublicHealthresearchfellowof the NationalCancerIn stitute, 1952—54.
منابع مشابه
Skin sterols. XII. Contrasting effects of certain mercaptans, amines, and related compounds on sterols and sebaceous glands.
The application of carcinogenic hydrocarbons to skin results in a rapid destruction of the seba ceous glands (3, 7, 13), and it has been suggested that a histological screening test for carcinogens might be based upon this phenomenon (13). Inde pendent studies on skin sterols have revealed that the application of carcinogens to rodent skin de creases the amount of A7-cholestenol in the epider m...
متن کاملBay region distortions in cyclopenta[a]phenanthrenes.
Two newly synthesized cyclopenta[a]phenanthrenes, namely the 1-methyl (VIII) and 7,11-dimethyl (VII) derivatives of the parent ketone 15,16-dihydrocyclopenta[a]phenanthren-17-one (I), have been tested for their capacity to produce skin tumors in mice. The former (VIII) is essentially inactive, whereas the latter (VII) is very potent in both repeated application and two-stage tests. X-ray crysta...
متن کاملBile acids, but not neutral sterols, are tumor promoters in the colon in man and in rodents.
Analysis of the etiologic factors and relevant mechanisms involved in carcinogenesis leads to a classification of agents involved in the carcinogenic process as genotoxic or epigenetic. Their mode of action is distinct, especially with regard to dose-response effects and reversibility. The genotoxic carcinogens for colon cancer are unknown, but mutagenic components found in fried beef and fish ...
متن کاملgenic Hydrocarbons : 1 : 2 - Benzanthracene , Chrysene , 1 : 2 : 5 : 6 †” Dibenzanthracene , and 20 - Methyicholanthrene
INTRODUCTION The summation or additive effects of carcino genie agents have received much attention in ef forts made to understand the action of carcinogens and the events that occur in carcinogenesis (5, 21). Chemical carcinogens, tumor-producing viruses, radiant energy, and trauma have been tried in various combinations (46) . Some agents showed summation, others did not, and a third group sh...
متن کاملCarcinogenicity of multiple chemicals simultaneously administered.
The possibility that several carcinogens may act concurrently in organs such as the lungs and skin has assumed greater importance as the nec ognized possible agents increase for these sites. A wide range of effects, from inhibition through no effects to summation or even synergism must be considered. The dosage, type of agents, portal of entry, duration of exposure, site and type of tissue, spe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 15 2 شماره
صفحات -
تاریخ انتشار 1955