13C Hyperpolarized Anticoagulants
نویسندگان
چکیده
J. Bargon, J. Bernarding, R. Rizi, H-W. Spiess, K. Münnemann, M. Roth, and U. Bommerich Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, NRW, Germany, Institute of Biometry, University of Magdeburg, Magdeburg, Germany, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, NMR, Max-Planck Institute of Polymers, Mainz, Germany, Institute of Neurobiology, Magdeburg, Germany
منابع مشابه
Hyperpolarized 13C Metabolic MRI of the Human Heart
RATIONALE Altered cardiac energetics is known to play an important role in the progression toward heart failure. A noninvasive method for imaging metabolic markers that could be used in longitudinal studies would be useful for understanding therapeutic approaches that target metabolism. OBJECTIVE To demonstrate the first hyperpolarized 13C metabolic magnetic resonance imaging of the human hea...
متن کاملThermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates
Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together with the constraint of having to polarize the 13C spins in a dedicated apparatus ...
متن کاملImaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.
In vivo spin spin relaxation time (T2) heterogeneity of hyperpolarized [13C,15N2]urea in the rat kidney was investigated. Selective quenching of the vascular hyperpolarized 13C signal with a macromolecular relaxation agent revealed that a long-T2 component of the [13C,15N2]urea signal originated from the renal extravascular space, thus allowing the vascular and renal filtrate contrast agent poo...
متن کاملIn Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging.
This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baselin...
متن کاملAssessing ischemic myocardial metabolism in vivo with hyperpolarized 13C: relating the metabolic perturbation to the area at risk
Background The high metabolic activity of the heart makes it particularly suited to the use of hyperpolarized (HP) 13C methods to non-invasively detect and characterize metabolic changes that occur during ischemia/reperfusion (I/R). Energy metabolism in ischemic rat hearts has been previously interrogated with HP 13C-labelled pyruvate ex vivo, and its hyperpolarized metabolites have been imaged...
متن کامل