Curbing Fear by Axonal Oxytocin Release in the Amygdala
نویسندگان
چکیده
Oxytocin produces anxiolytic effects via the central nucleus of the amygdala but how the peptide reaches its receptors in this region has been unclear. In this issue of Neuron, Knobloch et al. (2012) demonstrate that evoked oxytocin release from axon terminals within the central amygdala results in attenuation of fear.
منابع مشابه
Behavioural neuroscience: Taking axonal delivery of oxytocin : Article : Nature Reviews Neuroscience
Oxytocin affects various social behaviours by acting on forebrain regions including the amygdala, which has a key role in mediating fear responses. Nevertheless, how this neuropeptide reaches these regions has been a matter of debate. Now, Knobloch, Charlet et al. show that axons of oxytocin-positive hypothalamic neurons pervade many forebrain areas and that axonal oxytocin release from such ne...
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ورودعنوان ژورنال:
- Neuron
دوره 73 شماره
صفحات -
تاریخ انتشار 2012