CALL FOR PAPERS Neurological Disease and Autonomic Dysfunction Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia

نویسندگان

  • An N. Massaro
  • R. B. Govindan
  • Gilbert Vezina
  • Taeun Chang
  • Nickie N. Andescavage
  • Yunfei Wang
  • Tareq Al-Shargabi
  • Marina Metzler
  • Kari Harris
  • Adre J. du Plessis
چکیده

An N. Massaro, R. B. Govindan, Gilbert Vezina, Taeun Chang, Nickie N. Andescavage, Yunfei Wang, Tareq Al-Shargabi, Marina Metzler, Kari Harris, and Adre J. du Plessis Division of Neonatology, Children’s National Health System, Washington, District of Columbia; Division of Fetal and Transitional Medicine, Children’s National Health System, Washington, District of Columbia; Division of Diagnostic Imaging and Radiology, Children’s National Health System, Washington, District of Columbia; Department of Neurology, Children’s National Health System, Washington, District of Columbia; Department of Biostatistics and Study Methodology, Children’s National Health System, Washington, District of Columbia; and Department of Pediatrics, The George Washington University School of Medicine, Washington, District of Columbia

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Impaired cerebral autoregulation and brain injury in newborns with hypoxic-ischemic encephalopathy treated with hypothermia.

Impaired cerebral autoregulation may contribute to secondary injury in newborns with hypoxic-ischemic encephalopathy (HIE). Continuous, noninvasive assessment of cerebral pressure autoregulation can be achieved with bedside near-infrared spectroscopy (NIRS) and systemic mean arterial blood pressure (MAP) monitoring. This study aimed to evaluate whether impaired cerebral autoregulation measured ...

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Study of Neurodevelopmental Outcomes at 10-14 Months of Age Using Bayley Scale of Infant and Toddler Development in Asphyxiated Newborns with Hypoxic Ischemic Encephalopathy Treated with and without Therapeutic Hypothermia

Background: Therapeutic hypothermia has become an established protocol for all neonates with moderate to severe Hypoxic Ischaemic Encephalopathy (HIE). There are very few studies comparing the neurodevelopmental outcomes in asphyxiated neonates who received therapeutic hypothermia or did not. This study aimed to assess the neurodevelopmental outcomes of asphyxiated neonates with features of HIE...

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Hypothermia therapy for newborns with hypoxic ischemic encephalopathy.

OBJECTIVE Therapeutic hypothermia reduces cerebral injury and improves the neurological outcome secondary to hypoxic ischemic encephalopathy in newborns. It has been indicated for asphyxiated full-term or near-term newborn infants with clinical signs of hypoxic-ischemic encephalopathy (HIE). SOURCES A search was performed for articles on therapeutic hypothermia in newborns with perinatal asph...

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Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic–ischemic encephalopathy

Cerebral autoregulation represents the physiological mechanisms that keep brain perfusion relatively constant in the face of changes in blood pressure and thus plays an essential role in normal brain function. This study assessed cerebral autoregulation in nine newborns with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). These neonates received hypothermic therapy during the first 72...

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Candesartan Attenuates Ischemic Brain Edema and Protects the Blood–Brain Barrier Integrity from Ischemia/Reperfusion Injury in Rats

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

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تاریخ انتشار 2015