Short Communication Transamination in the Metabolism of the Nephrotoxicant N-(3,5- Dichlorophenyl)succinimide in Rats
نویسندگان
چکیده
Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania (D.C., P.J.H.); Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania (D.C.); and Department of Pharmacology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia (G.O.R.) DMD Fast Forward. Published on September 20, 2005 as doi:10.1124/dmd.105.006593
منابع مشابه
Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats.
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is nephrotoxic in rats. Due to the involvement of NDPS metabolism in its mechanism of toxicity, the detailed biotransformation of 14C-NDPS in rats was previously evaluated using high-performance liquid chromatography-electrospray ionization-mass spectrometry. In the present report, we describe the identification of two novel am...
متن کاملComparative disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide and the non-nephrotoxicant N-(3, 5-difluorophenyl)succinimide in Fischer 344 rats.
Disposition of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) was compared with that of a nontoxic analog, N-(3, 5-difluorophenyl)succinimide (DFPS). Male Fischer 344 rats were administered 0.2 or 0.6 mmol/kg [14C]NDPS or [14C]DFPS (i.p. in corn oil). Plasma concentrations were determined from blood samples obtained through the carotid artery. Urine samples were analyzed for metabo...
متن کاملIn vivo metabolism and disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide in Fischer 344 rats.
N-(3,5-Dichlorophenyl)succinimide (NDPS) was originally developed as an agricultural fungicide. Previous work indicated that NDPS-induced renal damage in rats is metabolism-dependent and that hydroxylated metabolites might be involved in the nephrotoxic response. In this study, the disposition and nephrotoxicity of [14C]NDPS at two time points (3 and 24 hr) and three doses (0.2, 0.4, and 0.6 mm...
متن کاملNephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) produces kidney damage in rats. Although many NDPS analogues have been screened as possible nephrotoxicants, the one-carbon homologue, N-(3,5-dichlorophenyl)glutarimide (NDPG), has not been evaluated. This study examined the nephrotoxic potential of NDPG and a putative metabolite, N-(3,5-dichlorophenyl)glutaramic acid (NDPGA). ...
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