Pii: S0304-3835(01)00726-1
نویسندگان
چکیده
MMI-166 is a selective inhibitor of matrix metalloproteinase (MMP)-2 and MMP-9. Mice implanted a human colon cancer orthotopically received 200 mg/kg of MMI-166 orally for 5 weeks. Gelatin zymography demonstrated that the administration of MMI-166 remarkably decreased the active MMP-2 expression. Histological examination revealed that MMI-166 showed prominent effect on reduction of the invasive feature of the cancer cells and showed inhibitory effect on tumor vasculature, resulting in the significant decrease of microvessel density of the implanted tumor and liver metastasis compared with the control group. Conclusively, MMI-166 is a potent antiangiogenic oral agent for a human colon cancer. q 2002 Elsevier Science Ireland Ltd. All rights reserved.
منابع مشابه
Pii: S0304-3835(01)00827-8
The effect of roscovitine, a purine analogue and cyclin dependent kinase inhibitor, on DNA synthesis rate in tissue mini-units obtained from human cervical cancers was investigated. Roscovitine (100 mM) gave a DNA synthesis rate inhibition by 61% (P , 0:0001; range 23–93%) within 30 min of incubation. This inhibitory effect was concentration-dependent. The results suggest that the inhibition of...
متن کاملPii: S0304-3835(01)00769-8
Fifteen pentacyclic triterpene diols and triols, consisting of: six taraxastanes, faradiol (1), heliantriol B0 (2), heliantriol C (3), 22a-methoxyfaradiol (4), arnidiol (5), and faradiol a-epoxide (6); five oleananes, maniladiol (7), erythrodiol (8), longispinogenin (9), coflodiol (10), and heliantriol A1 (11); two ursanes, brein (12) and uvaol (13); and two lupanes, calenduladiol (14) and heli...
متن کاملPii: S0304-3835(01)00676-0
It has long been known from work in both Drosophila and vertebrate systems that the hedgehog signalling pathway is pivotal to embryonic development, but the past 5 years has seen an increase in our understanding of how members of this pathway are crucial to the processes of tumorigenesis. This important link was firmly established with the discovery that mutations in the gene encoding the hedge...
متن کاملPii: S0304-3835(01)00655-3
Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anticancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin. Curcumin inhibited the cell growth of HT-29 c...
متن کاملPii: S0304-3835(01)00667-x
The rabbit VX2 tumor when implanted in the liver has proven convenient as a model for studying hepatocellular carcinomas. However, its metabolic properties have not been well studied. Significantly, studies described here show that the VX2 tumor exhibits a high glycolytic/high hexokinase phenotype that is retained following implantation and growth in rabbit liver. In addition, results of a limi...
متن کامل