TAZ Promotes PC2 Degradation through a SCF -Trcp E3 Ligase Complex †
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چکیده
TAZ Promotes PC2 Degradation through a SCF -Trcp E3 Ligase Complex † Yu Tian, Robert Kolb, Jeong-Ho Hong, John Carroll, Dawei Li, John You, Roderick Bronson, Michael B. Yaffe, Jing Zhou, and Thomas Benjamin* Department of Pathology and Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; and School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Seongbuk-Gu, Seoul 136-701, South Korea
منابع مشابه
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
Studies of a TAZ knockout mouse reveal a novel function of the transcriptional regulator TAZ, that is, as a binding partner of the F-box protein beta-Trcp. TAZ-/- mice develop polycystic kidney disease (PKD) and emphysema. The calcium-permeable cation channel protein polycystin 2 (PC2) is overexpressed in kidneys of TAZ-/- mice as a result of decreased degradation via an SCF(beta-Trcp) E3 ubiqu...
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