Is craving mood-driven or self-propelled? Sensitization and "street" stimulant addiction.
نویسندگان
چکیده
Pharmacological sensitization is defined as an increasing effect of a given drug dose after repeated administrations. Detected over 65 years ago during observations of animal behavior, sensitization provided an anti-thesis to the concept of pharmacological tolerance. In modern neuro-science, the sensitization concept has evolved to reflect neuroadaptive, or perhaps neurotoxic, processes and pharmacodynamics, rather than pharmacokinetic changes in plasma or brain concentrations of a drug.
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ورودعنوان ژورنال:
- NIDA research monograph
دوره 163 شماره
صفحات -
تاریخ انتشار 1996