Mast Cells Produce Interleukin-25 upon FcεRI-mediated Activation
نویسندگان
چکیده
Interleukin (IL)-25 is a recently described T helper 2 (Th2) cell-derived cytokine that belongs to IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non-T cell population. Here, we show that mast cells are also potent IL-25-producing cells. When bone marrow-derived mast cells (BMMCs) were stimulated by IgE cross-linking, IL-25 mRNA was induced within 30 min in a calcineurin-dependent manner and the levels of IL-25 mRNA were comparable to that of activated Th2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance Th2-type immune response by producing IL-25. Correspondence to Dr. Hiroshi Nakajima, e-mail: [email protected] For personal use only. on November 12, 2017. by guest www.bloodjournal.org From
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