Diversity Outbred: A New Generation of Mouse Model
نویسنده
چکیده
The use of genetically identical mice in toxicology studies can make it tricky to extrapolate findings to people. A new mouse model known as the Diversity Outbred better reflects the genetic diversity of the human population, offering intriguing possibilities for safety assessment.
منابع مشابه
New mouse models mimic biology of human cancer.
Scientists always try to develop mouse models that better represent human cancer and therapy. With two recent developments, those efforts have turned a corner. In one, investigators have published proof-of-principle findings with a highly outbred mouse that shows diverse responses to benzene, which causes human leukemia. This diversity outbred (DO) mouse represents an advanced model to derive h...
متن کاملMOUSE GENETIC RESOURCES High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
The JAX Diversity Outbred population is a new mouse resource derived from partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it segregates the same allelic variants as the Collaborative Cross but embeds these in a distinct population architecture in which each animal has a high degree of heterozygosity and carries a unique combination of alleles. Phe...
متن کاملHigh-resolution genetic mapping using the Mouse Diversity outbred population.
The JAX Diversity Outbred population is a new mouse resource derived from partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it segregates the same allelic variants as the Collaborative Cross but embeds these in a distinct population architecture in which each animal has a high degree of heterozygosity and carries a unique combination of alleles. Phe...
متن کاملEnhancement of NMRI Mouse Embryo Development In vitro
Most of the systematic studies used in the development of human embryo culture media have been done first on mouse embryos. The general use of NMRI outbred mice is a model for toxicology, teratology and pharmacology. NMRI mouse embryo exhibit the two-cell block in vitro. The objective of this study was to evaluate and compare the effects of four kinds of culture media on the development of zygo...
متن کاملMOUSE GENETIC RESOURCES Genome-Wide Association Mapping of Quantitative Traits in Outbred Mice
Recent developments in high-density genotyping and statistical analysis methods that have enabled genome-wide association studies in humans can also be applied to outbred mouse populations. Increased recombination in outbred populations is expected to provide greater mapping resolution than traditional inbred line crosses, improving prospects for identifying the causal genes. We carried out gen...
متن کامل