IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration. Sci Transl Med 6, 230ra44 (2014)
نویسنده
چکیده
1. Doyle SL, campbell M, Ozaki E, et al. NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat. Med. 2012; 18: 791– 798. 2. tarallo V, Hirano Y, Gelfand BD, et al. DIcER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. cell 2012; 149: 847–859. 3. Kauppinen A, Niskanen H, Suuronen t, et al. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for agerelated macular degeneration (AMD). Immunol. Lett. 2012; 147: 29–33. 4. tseng WA, thein t, Kinnunen K, et al. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: Implications for age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2013; 54: 110–120. Background
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