Is the ratio of flow - mediated dilation ( FMD ) and shear rate a statistically - sound approach to 2 normalization in cross - sectional studies on endothelial function ? 3 4
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چکیده
1 1 Is the ratio of flow-mediated dilation (FMD) and shear rate a statistically-sound approach to 2 normalization in cross-sectional studies on endothelial function? 3 4 Greg Atkinson, Alan M. Batterham, Mark A. Black, Nigel T. Cable, Nicola D. Hopkins, Ellen A. 5 Dawson, Dick.H.J. Thijssen, Helen Jones, Toni M. Tinken, Daniel J. Green 6 7 Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK 8 Department of Physiology, Radboud University Nijmegen Medical Centre, The Netherlands 9 School of Sport Science, Exercise and Health, The University of Western Australia, Australia 10 Health and Social Care Institute, School of Health and Social Care, Teesside University, UK 11 12 Running head: Normalization of FMD 13 14 15 Corresponding author: Prof. Greg Atkinson 16 Research Institute for Sport and Exercise Sciences 17 Liverpool John Moores University 18 Henry Cotton Campus 19 Webster Street 20 Liverpool L3 2ET, UK 21 Tel. +44 (0) 151 231 4249 22 Fax +44 (0) 151 231 4353 23 Email: [email protected] 24 Articles in PresS. J Appl Physiol (October 15, 2009). doi:10.1152/japplphysiol.00779.2009
منابع مشابه
Is the ratio of flow-mediated dilation and shear rate a statistically sound approach to normalization in cross-sectional studies on endothelial function?
It has been deemed important to normalize flow-mediated dilation (FMD), a marker of endothelial function, for between-subject differences in the eliciting shear rate (SR) stimulus. Conventionally, FMD is divided by the area under the curve of the SR stimulus. In the context of a cross-sectional comparison across different age cohorts, we examined whether this ratio approach adhered to establish...
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BACKGROUND/AIMS Although normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress (FMD:shear stress ratio) has been proposed to improve this measure of endothelial function, the clinical utility of FMD normalization has not yet been demonstrated. We tested (1) whether following conventional 5-min forearm occlusion, the FMD:shear stress ratio would discriminate a ...
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Introduction: Flow mediated-dilation (FMD) is a noninvasive test of endothelial function based on shear stressdependent nitric oxide secretion causing vasodilation. Normalization of FMD to shear stress was previously proposed. The aim of present study is an examination of relationship between shear rate and FMD in patients with hypertension and atherosclerosis in comparison with healthy volunte...
متن کاملNormalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus
BACKGROUND Normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress area under the curve (peak FMD:SSAUC ratio) has recently been proposed as an approach to control for the large inter-subject variability in reactive hyperemia-induced shear stress; however, the adoption of this approach among researchers has been slow. The present study was designed to further ex...
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