On hedgehogs and human cancer

نویسندگان

  • A Ruiz i Altaba
  • F Varnat
چکیده

in vitro, specifically decreasing GLI1 messenger RNA (mRNA) levels, at concentrations ranging from 1 to 10mM showing dose-dependent effects, modulated by serum levels. The best tests for specificity rely on mimicry by targeting SMOH with RNA interference (RNAi), the use of insensitive SMOH mutants and pathway epistatic analyses. Targeting SMOH through lentivector-mediated short hairpin RNA (shRNA) silencing mimics

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عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2010