A review of maternally inherited diabetes and deafness.
نویسندگان
چکیده
Maternally inherited diabetes and deafness (MIDD), a mitochondrial disease first described in 1992, results from the mitochondrial DNA mutation and affects up to 1% of the patients with diabetes. This review discusses the biomedical mechanisms of MIDD patients; summarizes the recent improvement of clinical and genetic diagnosis of MIDD; outlines the advances of the clinical management of these patients and their families.
منابع مشابه
Maternally-inherited diabetes with deafness (MIDD) and hyporeninemic hypoaldosteronism.
Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenic diabetes that results, in most cases, from an A-to-G transition at position 3243 of mitochondrial DNA (m.3243A>G) in the mitochondrial-encoded tRNA leucine (UUA/G) gene. As the name suggests, this condition is characterized by maternally-inherited diabetes and bilateral neurosensory hearing impairment. A characterist...
متن کاملMaternally Inherited Type 2 Diabetes and Deafness: Clinical and Molecular Aspect in Pakistan
Background:. A3243G mutation in tRNA Leu (UUR) leads to a specific clinical syndrome characterized by diabetes and sensorineural hearing defect, hence called as “Maternally Inherited Diabetes and Deafness (MIDD)”.. Methods: The study was retrospective, analytical case control study. Non probability convenient sampling technique was used. Subjects were divided into two groups. Thirty-nine patien...
متن کاملUnusual Occurrence of Intestinal Pseudo Obstruction in a Patient with Maternally Inherited Diabetes and Deafness (MIDD) and Favorable Outcome with Coenzyme Q10
Maternally inherited diabetes and deafness (MIDD) has been related to an A to G transition in the mitochondrial tRNA Leu (UUR) gene at the base pair 3243. This subtype of diabetes is characterized by maternal transmission, young age at onset and bilateral hearing impairment. Besides diabetes and deafness, the main diagnostic features, a wide range of multisystemic symptoms may be associated wit...
متن کاملA Report on the Prevalence of 15 Mitochondrial DNA Mutations Amongst Type 2 Diabetic Patients with or without Clinical Characteristics of Maternally Inherited Diabetes and Deafness
The aim of the present study is to investigate the prevalence of ten described mitochondrial DNA (mtDNA) mutations in patients with type 2 diabetes, and search for new mutations in four mtDNA genes in a subgroup of patients with characteristics of maternally inherited diabetes and deafness (MIDD). These mutations were investigated in 407 type 2 diabetic patients without characteristics of mitoc...
متن کاملUnusual occurrence of intestinal pseudo obstruction in a patient with maternally inherited diabetes and deafness (MIDD) and favorable outcome with coenzyme Q10.
Maternally inherited diabetes and deafness (MIDD) has been related to an A to G transition in the mitochondrial tRNA Leu (UUR) gene at the base pair 3243. This subtype of diabetes is characterized by maternal transmission, young age at onset and bilateral hearing impairment. Besides diabetes and deafness, the main diagnostic features, a wide range of multisystemic symptoms may be associated wit...
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عنوان ژورنال:
- Frontiers in bioscience
دوره 19 شماره
صفحات -
تاریخ انتشار 2014