Upstream stimulatory factors stimulate transcription through the E-box motifs in the PF4 gene in megakaryocytes
نویسندگان
چکیده
Yoshiaki Okada, Eri Matsuura, Zenzaburo Tozuka, Ryohei Nagai, Ayako Watanabe, Kayoko Matsumoto, Kazuta Yasui, Robert W. Jackman, Toru Nakano and Takefumi Doi* Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan Biopharmaceutical and Pharmacokinetics Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Yodogawa-ku, Osaka 532-8514, Japan Osaka Red Cross Blood Center, 2-4-43 Morinomiya, Johtoh-ku, Osaka 536-8505, Japan Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA 02215, USA Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
منابع مشابه
Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes.
Platelet factor 4 (PF4) is expressed during megakaryocytic differentiation. We previously demonstrated that the homeodomain proteins (myeloid ecotropic integration site 1 [MEIS1], Pbx-regulating protein 1 [PREP1], and pre-B-cell leukemia transcription factors [PBXs]) bind to the novel regulatory element tandem repeat of MEIS1 binding element [TME] and transactivate the rat PF4 promoter. In the ...
متن کاملUpstream stimulatory factors stimulate transcription through the E-box motifs in the PF4 gene in megakaryocytes Short title: USF1 and 2 regulate PF4 gene expression in megakaryocytes
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The transcription factor TFII-I has been shown to bind independently to two distinct promoter elements, a pyrimidine-rich initiator (Inr) and a recognition site (E-box) for upstream stimulatory factor 1 (USF1), and to stimulate USF1 binding to both of these sites. Here we describe the isolation of a cDNA encoding TFII-I and demonstrate that the corresponding 120 kDa polypeptide, when expressed ...
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