The Arthus Phenomenon Local Anaphylactic Inflammation in the Rabbit Brain

The brain as a functional unit in the production of generalized anaphylaxls has been extensively studied, notably by Besredka (1). As the seat of a local allergic reaction, however, it has apparently not yet been examined. Since the local anaphylactic reaction in the skin and in various organs (2) consists of edema, hemorrhage, and leucocytic infiltration, it appeared likely that the nervous tissue, which is so susceptible to the above mentioned pathological changes from a great variety of causes, would lend itself particularly well to the production of anaphylactic lesions. In the present paper we have attempted to demonstrate the occurrence of local anaphylaxis in the brain of the rabbit.