Formulation Design and Optimization of Fast Dissolving Effervescent Tablets of Clonazepam
نویسندگان
چکیده
tablet formulation (t 16.4 min). Short-term stability studies on the formulation indicated that there are no significant changes in drug 50% content and in vitro dispersion time (p<0.05).
منابع مشابه
Formulation Design and Optimization of Fast Dissolving Clonazepam Tablets by Sublimation Method
Fast dissolving tablets of clonazepam were prepared by sublimation method with a view to enhance patient compliance. A 3(2) full factorial design was applied to investigate the combined effect of two formulation variables: amount of croscarmellose sodium and camphor. Croscarmellose sodium (2-8% w/w) was used as superdisintegrant and camphor (20-40% w/w) was used as subliming agent, to increase ...
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